DP 4978

Name	LY3009120
Synonyms	DP 4978 CS-1616 DP4978 DP 4978 DP-4978 LY3009120 LY-3009120 LY03009120 LY 3009120 LY-3009120 N-(3,3-dimethylbutyl)-N'-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]- N-(3,3-Dimethylbutyl)-N'-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]urea Urea, N-(3,3-dimethylbutyl)-N'-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]-
CAS	1454682-72-4

Molecular Formula	C23H29FN6O
Molar Mass	424.51
Density	1?+-.0.06 g/cm3(Predicted)
Solubility	DMSO : ≥ 38 mg/mL (89.51 mM)
pKa	13.52±0.70(Predicted)
Storage Condition	-20℃
Use	LY3009120 is a pan-RAF inhibitor, which inhibits BRAFV600E,BRAFWT and CRAWT with IC50 of 5.8,9.1 and 15 nM, respectively.
In vitro study	LY3009120 inhibited the growth of A375 and HCT116 cells with an IC50 of 9.2 and 220 μm, respectively. LY3009120 inhibits the tyrosine kinase KDR with an IC50 of 3.9 μm.
In vivo study	LY3009120 (15 or 30 mg/kg, p.o.) dose-dependently inhibited tumor growth in rats bearing BRAF V600E ST019VR PDX tumors. In nude mice bearing A375 xenografts, LY3009120 (3 to 50 mg/kg, p.o.) single dose of oral treatment dose-dependent inhibition of phosphate-ERK,4.36 mg/kg dose inhibition of 50% phosphate-ERK (EC50),68.9 inhibition of phospho-ERK (EC50) was achieved at 165 ng/mL or 50% nM plasma concentration.

Last Update：2024-01-02 23:10:35

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Product Name: LY3009120 Visit Supplier Webpage Request for quotation
CAS: 1454682-72-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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DP 4978

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